First Ever Once-Weekly Diabetes Treatment Injection

By Anonymous on March 9, 2010 – 10:00am for eMaxHealth
Diabetes Care
Amylin, Lilly and Alkermes have joined forces to get exenatide once weekly, a subcutaneous injection of exenatide for the treatment of type 2 diabetes on the market. The drug is in a grouping of many new longer lasting type 2 diabetes treatment drugs that have had effective results without the risk of hypoglycemia. Exenatide could be approved on Friday, March 12 after a 5-day interruption by the Food and Drug Administration for weather-related problems.

The new exenatide is the answer to millions of type 2 diabetes patients who are unable to control their blood sugar with daily insulin injections. The side effects from the drug are extensive, but most diabetes treatment drugs cause similar issues, such as stomach problems, dizziness, jittery feelings, skin irritation and decreased urination.

“Exenatide once weekly is an investigational, extended-release medication for type 2 diabetes designed to deliver continuous therapeutic levels of exenatide in a single weekly dose. The NDA for exenatide once weekly was submitted in May 2009 and accepted by the FDA in July 2009.”

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FIVE EASY WAYS TO MAKE YOUR DIABETES LIFE EASY

Most diabetics can confess that sometimes it’s hard to motivate ourselves in making healthier decisions when it comes to managing our diabetes. From various diets, exercises, and life style changes, it doesn’t have to be hard.

Take it from this type 1 diabetic as he shares with us five easy ways to improve our diabetic life without any drastic changes. You can be the boss of your diabetes!

How to Stop Diabetes From Starting

By TAMARA DUKER FREUMAN
April 2, 2013 RSS Feed Print

Tamara Duker Freuman
The Centers for Disease Control and Prevention (CDC) released a shocking statistic a few weeks ago: Eighty-nine percent of the 79 million Americans with pre-diabetes are not even aware they have the condition. In other words, there are 70.3 million Americans over the age of 20 at high risk for developing diabetes at any moment … and they don’t even know it.

This is troubling for several reasons. For starters, diabetes is a chronic condition associated with a reduced life expectancy; the average 50 year old with diabetes loses an estimated 8 1/2 years of longevity. Prevention, therefore, translates into increased likelihood of a substantially longer life—the end of which is less likely to be spent shuttling to and from doctor’s offices and hospitals. Secondly, there are several established ways to delay—if not entirely prevent—the onset of diabetes in people with prediabetes.

But unless you know you’re at risk, it’s unlikely you’ll stumble upon these preventive measures in time to halt the progression toward full-fledged diabetes. In any given year, about 11 percent of people with prediabetes “graduate” to developing diabetes.

[See Diet, Diabetes and Doubt: Is Preventive Medicine Lost in Space?]

Prediabetes is a condition in which your ability to handle blood sugar is impaired, but not so impaired as to qualify for full-blown diabetes. It results from reduced sensitivity to the hormone insulin, which helps carry glucose from the blood into cells where it can be used for energy.

Importantly, pre-diabetes is reversible; glucose tolerance can improve when a person’s metabolic state of affairs improves. Here’s how:

• Very moderate exercise. You don’t need to spend hours every day sweating up a storm in a spin class to reap the diabetes-preventing effects of exercise. Heck, you don’t even need to join a gym. Research suggests that 2 1/2 hours per week of even leisurely physical activity—like brisk walking—is enough to significantly improve glucose tolerance. This translates into a 30-minute walk five times per week—though of course, if you’re up to the challenge, more is even better. Exercise works because muscles in action are able to take up glucose from the blood without the help of insulin, so get moving!

[See 7 Mind-Blowing Benefits of Exercise.]

• Very modest weight loss. Evidence suggests that it only takes about a 5 to 7 percent weight loss to delay by several years the onset of diabetes among overweight people with prediabetes. To put that in perspective, a 5-foot-4-inch woman with pre-diabetes who weighs 160 pounds would only need to lose about 11 pounds to reduce her risk of developing diabetes. A five-foot-11-inch man weighing 220 pounds would need to lose about 15 pounds to hit this target. In other words, one doesn’t have to drop dramatic, “The Biggest Loser”-scale amounts of weight to help protect against diabetes. In some people, small lifestyle changes like avoiding sweetened beverages or decreasing carb portions may be sufficient to promote this degree of weight loss.

[See When Science Met The Biggest Loser.]

In fact, research has shown that modest weight loss, coupled with 150 minutes of weekly exercise, reduced by 58 percent the risk of developing diabetes in a population of obese adults with prediabetes. Specifically, participants who started off weighing an average of 207 pounds lost about 12 pounds (or 5.7 percent of their body weight). Notably, this outcome was substantially more effective than using an insulin-sensitizing drug called metformin in preventing the onset of diabetes.

• Curcumin supplements. Recent research out of Thailand that was published in Diabetes Care suggested that supplementing curcumin—the active ingredient in the bright yellow, anti-inflammatory spice turmeric—may be protective against diabetes among people with pre-diabetes.

[See Dr. Weil’s Anti-Inflammatory Diet.]

Although it was only a single, small study (237 people), it was well designed and showed a very promising clinical benefit: Of the group randomly assigned to take 500 milligrams of curcumin supplements three times daily, none progressed to develop type 2 diabetes after nine months. By way of comparison, 16 percent of participants in the placebo group did develop type 2 diabetes in the same time period.

Since the research population was homogeneously Asian, it’s not clear whether these results can be extrapolated to a general American population. And since the study was short, it’s unclear whether the protective benefit would have extended past the nine months studied. Nonetheless, given how inexpensive and well-tolerated this natural supplement tends to be, it may be worth talking with your doctor or dietitian to see if curcumin is an appropriate supplement for you to consider.

With 70 million of us counted among the unknowing ranks of adults with pre-diabetes, it’s statistically likely that you or someone you know belongs to this group. Risk factors for pre-diabetes include being overweight or obese; having a family history of diabetes; having a personal history of gestational diabetes in pregnancy; having given birth to a baby weighing more than nine pounds; and belonging to one of several ethnic groups, including African American, Hispanic, Asian American, Pacific Islander or Native American. If you fall into one of these categories, consider making an appointment for a check-up; prediabetes can be assessed with simple blood tests from your primary care doctor.

Knowing your status could make a huge difference in turning the tide against progression to diabetes before it’s too late.

[See 7 Things to Know if You’ve Received a Diabetes Diagnosis.]

Hungry for more? Write to eatandrun@usnews.com with your questions, concerns, and feedback.

Tamara Duker Freuman, MS, RD, CDN, is a NYC-based registered dietitian whose clinical practice specializes in digestive disorders, Celiac Disease, and food intolerances. Her personal blog, www.tamaraduker.com, focuses on healthy eating and gluten-free living.

Four Type 2 Diabetes Drugs Approved in 3 Months, Not Good Enough

By Deborah Mitchell on March 31, 2013 – 8:33am for eMaxHealth
Diabetes Care Current News

In just 3 months, the Food and Drug Administration (FDA) has granted approval to four type 2 diabetes drugs, including Invokana, which is the first in its class. Yet while adding new items to the expanding type 2 diabetes drugs arsenal has its positive side, it’s not good enough, and here’s why.

Do we need four new type 2 diabetes drugs?
It’s no secret that type 2 diabetes is a growing epidemic, and that an increasing number and percentage of children and adolescents are developing this disease that was once largely seen only in adults. For young people in particular, onset of type 2 diabetes at an early age places them at greater risk for a lifetime of health complications and a shorter life span.

The four new type 2 diabetes drugs that won FDA approval since January 2013, including the latest, Johnson & Johnson’s Invokana (canaglifozin), provide current and future type 2 diabetics with more pharmaceutical treatment options. Before looking at those four new options, let’s consider how much they are needed.

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Get More Energy to Exercise

By Gina Shaw, 2013
Too tired to get moving? These practical exercise tips will give you the jump start you need to be more active, lose weight, manage your diabetes — and help you figure out what’s draining your energy in the first place.

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What’s Slowing You Down?
It’s a message you hear everywhere: Exercise is one of the most important things you can do to control your diabetes. It’s also a catch-22: Controlling diabetes can be so exhausting that some days just leaving the house feels like climbing a mountain.

Why is lack of energy such a big problem for people with diabetes (PWDs)? And what can you do about it?

One big cause is an imbalance in blood glucose. “If your blood sugar is out of control in either direction — too high or too low — you can feel tired and drained,” says Aaron Vinik, M.D., Ph.D., director of the Strelitz Diabetes Center at Eastern Virginia Medical School in Norfolk. Many PWDs also must cope with other factors, such as high blood pressure and excess weight, that can make you feel as if there’s a giant hole in the tank of your energy reserves.

It doesn’t have to be this way. You can find the energy to exercise — you just need to know where to look.

Next: Start Small

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